2022 |
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Park, Jongmin; Park, Eunsook; Choi, Siyoung Q; Wu, Jingxian; Park, Jihye; Lee, Hyeonju; Kim, Hyungjun; Lee, Haeshin; Seo, Myungeun Biodegradable block copolymer–tannic acid glue Journal Article JACS Au, 2 (9), pp. 1978–1988, 2022, ISSN: 2691-3704. Abstract | BibTeX | Tags: Adhesive Block polymer Micelles Phase separation Thermoresponsive polymers @article{Seo2022e, title = {Biodegradable block copolymer–tannic acid glue}, author = {Jongmin Park AND Eunsook Park AND Siyoung Q. Choi AND Jingxian Wu AND Jihye Park AND Hyeonju Lee AND Hyungjun Kim AND Haeshin Lee AND Myungeun Seo}, url = {https://pubs.acs.org/doi/10.1021/jacsau.2c00241}, doi = {10.1021/jacsau.2c00241}, issn = {2691-3704}, year = {2022}, date = {2022-08-22}, journal = {JACS Au}, volume = {2}, number = {9}, pages = {1978–1988}, abstract = {Bioadhesives are becoming an essential and important ingredient in medical science. Despite numerous reports, developing adhesive materials that combine strong adhesion, biocompatibility, and biodegradation remains a challenging task. Here, we present a biocompatible yet biodegradable block copolymer-based waterborne superglue that leads to an application of follicle-free hair transplantation. Our design strategy bridges self-assembled, temperature-sensitive block copolymer nanostructures with tannic acid as a sticky and biodegradable polyphenolic compound. The formulation further uniquely offers step-by-step increases in adhesion strength via heating–cooling cycles. Combining the modular design with the thermal treating process enhances the mechanical properties up to 5 orders of magnitude compared to the homopolymer formulation. This study opens a new direction in bioadhesive formulation strategies utilizing block copolymer nanotechnology for systematic and synergistic control of the material’s properties.}, keywords = {Adhesive, Block polymer, Micelles, Phase separation, Thermoresponsive polymers}, pubstate = {published}, tppubtype = {article} } Bioadhesives are becoming an essential and important ingredient in medical science. Despite numerous reports, developing adhesive materials that combine strong adhesion, biocompatibility, and biodegradation remains a challenging task. Here, we present a biocompatible yet biodegradable block copolymer-based waterborne superglue that leads to an application of follicle-free hair transplantation. Our design strategy bridges self-assembled, temperature-sensitive block copolymer nanostructures with tannic acid as a sticky and biodegradable polyphenolic compound. The formulation further uniquely offers step-by-step increases in adhesion strength via heating–cooling cycles. Combining the modular design with the thermal treating process enhances the mechanical properties up to 5 orders of magnitude compared to the homopolymer formulation. This study opens a new direction in bioadhesive formulation strategies utilizing block copolymer nanotechnology for systematic and synergistic control of the material’s properties. |